Catheter-tip cultures not useful for diagnosing central line-associated infection

By Will Boggs MD

NEW YORK (Reuters Health) - Catheter-tip cultures are not helpful for identifying central line-associated blood stream infections (CLABSI), researchers say.

Their letter, published online October 29 in Clinical Infectious Diseases, argues against guidelines from the Infectious Disease Society of America (IDSA), which recommend the method when diagnosing CLABSI.

FDA approves Purdue's painkiller that can reduce abuse

By Toni Clarke

(Reuters) - The U.S. Food and Drug Administration has approved a long-acting narcotic painkiller with abuse-resistant properties made by Purdue Pharma L.P., the agency said on Thursday.

The FDA approved the once-daily drug, hydrocodone bitartrate (Hysingla ER), with the expectation that it will reduce, though not necessarily prevent, abuse through snorting or injecting.

It is the second extended-release single-entity hydrocodone drug approved by the FDA. The first, approved last October, was Zohydro ER, made by San Diego-based Zogenix Inc.

Bone marrow cells that contribute to bone loss in IBD identified

By Reuters Staff

NEW YORK (Reuters Health) - French researchers say they have identified CD4+ T cell subsets that induce osteoclast differentiation and link bone destruction to inflammatory bowel disease (IBD).

These cells "represent a potential target for innovative immunotherapeutic strategies against chronic intestinal inflammation and bone loss," Dr. Thomas Ciucci of University of Nice Sophia Antipolis and colleagues say in a paper published in Gut.

Some forms of early-onset Crohn's disease linked to polymorphisms

By Lorraine L. Janeczko

NEW YORK (Reuters Health) - Some Mendelian forms of early-onset Crohn's disease with systemic autoimmunity may arise from mutations in the CTLA4 gene, new research suggests.

"Our results support the concept that variants in CTLA4 provide the basis for a novel Mendelian form of early-onset CD associated with systemic autoimmunity," the authors reported online November 3 in Gut.

No effect of vitamin B on cognition in healthy elderly with hyperhomocysteinemia

By Anne Harding

NEW YORK (Reuters Health) - Folic acid and vitamin B12 supplementation does not affect cognitive performance in healthy older people with elevated homocysteine levels, according to a new two-year trial.

Hyperhomocysteinemia has been linked to cognitive decline and dementia, Dr. Rosalie Dhonukshe-Rutten of Wageningen University in the Netherlands and her colleagues note in Neurology, online November 12.