The Management of Diabetic Neuropathy and Glycemic Control in Long-Term Care Facilities (Part III of III)
- Tue, 1/13/09 - 3:38pm
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Pathophysiology
How Does Diabetes Mellitus Cause Nerve Damage?
Although the pathophysiology of diabetic neuropathy is unclear, most experts believe that hyperglycemia is the cause of the nerve damage in DPN.48 Hyperglycemia causes increased levels of intracellular glucose in nerves, leading to saturation of the normal glycolytic pathway.49 Nevertheless, different neuropathies may have different (and perhaps overlapping) mechanisms; for example, with focal or asymmetrical diabetic neuropathy syndromes, vascular injury or autoimmunity may play more important roles
