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Treatment of Alcohol-Related Problems in the Elderly

  • Fri, 9/5/08 - 5:54pm
  • 0 Comments
  • 6430 reads
Author(s): 

Julian Offsay, MD

Although figures vary from one study to another, available evidence indicates that alcoholism in the elderly is underdiagnosed and undertreated.1 Community studies generally have shown that about 2-3 percent of men over the age of 65 years meet criteria for alcoholism, with the incidence in women being perhaps one-third of that.2,3 When the focus is shifted to the medical office or the inpatient setting, the figures may increase tenfold, and are usually even higher for elderly persons seen in the emergency room.4 Furthermore, there is a general consensus that with the aging of the “baby boom” generation, these figures will increase significantly.

Among older drinkers there appears to be two different groups in terms of age of onset of alcoholic drinking (Table I).5 “Early-onset” alcoholics tend to comply with the common stereotype of the chronic alcoholic. They typically begin as teenagers or in their early twenties, and often impair their health, vocational life and personal relationships severely as they progress from youth through middle age. Many do not reach old age for obvious reasons. “Later-onset” alcoholics are mainly people who drank moderately, or even rarely, but then either increased their intake in association with the changes brought about by the aging process, or ran into problems because they could no longer handle the amount of alcohol they consumed earlier in life. Among the physiologic changes that account for reduced tolerance in the elderly are a decrease in lean tissue and water, with a relative increase in fatty tissue. Accordingly, a given amount of alcohol is distributed in a smaller volume, and blood levels are higher. Also, older people have less alcohol dehydrogenase in their stomachs, so, again, a drink raises blood levels more than it did at a younger age. Furthermore, the elderly brain is far more sensitive to alcohol.

Evaluating a Patient with an Alcohol Problem
In order to assess the severity of a given patient’s alcohol problem, we inquire about the quantity and pattern of drinking. A “standard drink” contains between ½ and ¾ ounce of pure alcohol. This is approximately the amount in a shot of 80-proof liquor, a 12-ounce glass of beer, or a 5-ounce glass of wine. The current recommendation, from the National Institute on Alcohol Abuse and Alcoholism, is that persons over age 65 limit their consumption to one standard drink per day, and to no more than two on any occasion. Women are more vulnerable to alcohol’s deleterious effects and are generally advised to drink less. (Guideline is available in Treatment Improvement Protocol # 26, available from the Substance Abuse and Mental Health Services Administration [SAMHSA].6 The reader is advised to visit the SAMHSA site on the Internet [http://samhsa.gov], as it is a source of valuable information and publications).

The terms at risk and problem drinking have been found useful in terms of evaluating severity. At risk is drinking that has not yet led to identifiable consequences, but which is likely to do so in the future. Problem drinking pertains to a pattern that has led to one or more adverse consequences. The labels of alcohol abuse and dependence define conditions of greater magnitude. Abuse generally involves major consequences in at least one area of functioning, while a dependence diagnosis requires widespread impairment, with the addiction essentially taking over one’s life. Actual tolerance and physical dependence are usually present to some degree, but are not required to make the diagnosis.

In order to accurately identify alcoholic problems in patients, clinicians must be actively searching for them and asking the right questions.

References: 

References
1. McInnes E, Powell J. Drug and alcohol referrals: Are elderly substance abuse diagnoses and referrals being missed? BMJ 1994:308:444-446.

2. Grant BF. Prevalence and correlates of alcohol use and DSM-IV Alcohol dependence in the United States: Results of the National Longitudinal Alcohol Epidemiologic Survey. J Stud Alcohol 1997;58:464-473.

3. Helzer JE, Burnam A, Mc Evoy LT. Dependence. In: Robins LN, Regier DA, eds. Psychiatric Disorders in America. The Epidemiologic Catchment Area Study. New York, NY: Free Press; 1991:81-115.

4. Speer DC, Bates K. Comorbid mental and substance use disorders among older psychiatric patients. J Am Geriatr Soc 1992;40:886-890.

5. Liberto JG, Oslin DW. Early versus late onset of alcoholism in the elderly. Int J Addict 1995:30:1799-1818.

6. Blow FC. TIP 26: Substance abuse among older adults. 1998. Available at: http://ncadi.samhsa.gov/govpubs/BKD250. Accessed May 11, 2007.

7. Ewing JA. Detecting alcoholism, The CAGE questionnaire. JAMA 1984:252:1905-1907.

8. Blow FC, Brower KJ, Schwenberg JE, et al. The Michigan Alcoholism Screening Test-Geriatric Version (MAST-G). A new elderly-specific screening instrument. Alcohol Clin Exp Res 1992;16:372.

9. Babor TF, de la Fuente JR, Saunders J, Grant M. AUDIT: The Alcohol Use Disorders Identification Test: Guidelines for use in primary health care. Geneva, Switzerland: World Health Organization, 1992.

10. Talbott GD, Wilson PO. Physicians and other health professionals. In: Lowinson JH, Ruiz P, Millman RB, et al, eds. Substance Abuse, A Comprehensive Textbook. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005:1190-1191.

11. Fleming MF, Manwell LB, Barry KL, et al. Brief physician advice for alcohol problems in older adults: A randomized community-based trial. J Fam Pract 1999:48(5):378-384.

12. Barry KL, Oslin DW, Blow FC. Prevention and Management of Alcohol Problems in Older Adults. New York, NY: Springer Publishing; 2001.

13. Miller W, Rollonick S. Motivational Interviewing: Preparing People to Change Addictive Behavior. New York, NY: The Guilford Press; 1991.

14. Stuppaeck CH, Barnas C, Falk M, et al. Assessment of the alcohol withdrawal syndrome: Validity and reliability for the translated and modified Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-A). Addiction 1994,89:1287-1292.

15. Volpicelli JR, Alterman AI, Hayashida M, O’Brien CP. Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 1992;49:876-880.

16. O’Malley SS, Jaffe AJ, Chang G, et al. Naltrexone and coping skills therapy for alcohol dependence: A controlled study. Arch Gen Psychiatry 1992;49:881-887.

17. Oslin DW, Liberto JG, O’Brien J, et al. Naltrexone as an adjunctive treatment for older patients with alcohol dependence. Am J Geriatric Psychiatry 1997;5(4):324-332.

18. Oslin DW, Pettinati H, Volpicelli JR. Alcoholism treatment adherence: Older age predicts better adherence and drinking outcomes. Am J Geriatr Psychiatry 2002;10(6):740-747.

19. Garbutt JC, Kranzler HR, O’Malley, et al; Vivitrex Study Group. Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: A randomized controlled trial. JAMA 2005;293:1617-1625. [Erratum in: JAMA 2005;293(16):1978. Erratum in: JAMA 2005;293(23):2864.]

20. Anton RF, O’Malley SS, Ciraulo DA, et al; COMBINE Study Group. Combined pharmacotherapies and behavioral interventions for alcohol dependence: The COMBINE study: A randomized controlled trial. JAMA 2006;295:2003-2017.

21. Kranzler HR, Burleson JA, Brown J, Babor TF. Fluoxetine treatment seems to reduce the beneficial effect of cognitive-behavioral therapy in type B alcoholics. Alcohol Clin Exp Res 1996;20(9):1534-1541.

22. Pettinati HM, Volpicelli JR, Kranzler HR, et al. Sertraline treatment for alcohol dependence: Interactive effects of medication and alcoholic subtype. Alcohol Clin Exp Res 2000;24(7):1041-1049.

23. Kofoed LL, Tolson RL, Atkinson RM, et al. Treatment compliance of older alcoholics: An elder-specific approach is superior to “mainstreaming.” J Stud Alcohol 1987;48(1):47-51.

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