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Management of Diabetes Mellitus in the Nursing Home

  • Fri, 9/5/08 - 4:54pm
  • 0 Comments
  • 3204 reads
Author(s): 

Danelle Cayea, MD, MS, and Samuel C. Durso, MD

INTRODUCTION
Diabetes mellitus (DM), primarily type 2, is a prevalent, resource-intensive condition in nursing homes (NHs), which may have significant impact on residents’ function and quality of life. Upon admission to a NH, 26.4% of residents have a diagnosis of DM, including short-stay (< 6 months) and long-stay residents (> 6 months), whose placement may be permanent.1 Almost half of residents with DM will become long-stay residents.1 Compared to those admitted without DM, residents with DM have a higher burden of comorbid disease, disability, and cognitive impairment, pain, depression, polypharmacy, and require more nursing care.1 Older adults with DM are at higher risk of developing several geriatric syndromes, including injurious falls,2,3 incident disability,4 cognitive impairment,5 urinary incontinence (UI),6 depression,7 and persistent pain,8 if not already present. While the goals of care for short-stay and long-stay residents may differ, avoiding iatrogenic harm is a major focus for both. This is particularly true for frail NH residents with DM who are at high risk for hypoglycemia or other complications of medical therapy such as postural hypotension.

As a result, management of DM in the long-term care setting requires supreme clinical judgment, taking into account the resident’s care preferences, comorbid conditions, and estimated life expectancy. All of this information must be used to make a realistic assessment of the likely benefits and risks of treatment for DM, and associated conditions consistent with the resident’s short- and long-term goals.

In 2003, an expert panel convened by the California Healthcare Foundation/American Geriatrics Society published Guidelines for Improving the Care of the Older Person with Diabetes Mellitus. The major aim of the guideline was to provide clinicians with a framework for prioritizing recommendations for the management of glycemia, and preventing micro- and macrovascular disease in the population of older adults with DM and heterogeneous health status.9 The guideline noted that while intensive risk management is appropriate for robust older adults with good function, it might be inappropriate in frail older adults with limited life expectancy, where the focus of care often shifts to prevention of symptomatic hyperglycemia and reduction of the burden of medical therapy. Furthermore, the guideline noted that geriatric syndromes might complicate the management of DM or constitute a primary focus of care. As a result, it recommended that healthcare providers screen for and manage geriatric syndromes. The guideline provides the basics of a framework to help clinicians prioritize competing comorbidities. Subsequent guidelines by the American Diabetes Association have included explicit reference to these guidelines and have endorsed its message.10 In addition, process-based quality indicators for long-stay NH residents with DM have been developed in an effort to improve outcomes while keeping the unique needs of this population in mind.11

In addition to these considerations (ie, comorbid illness, geriatric syndromes, reduced life expectancy, and shifting priorities of care), physicians and other healthcare providers practicing in the long-term care setting often find that managing residents with DM is complicated by care transitions, dependency that affects food and water intake, and conditions such as dementia and stroke that interfere with patient-provider communication.

References: 

References

1. Travis SS, Buchanan RJ, Wang S, Kim M. Analyses of nursing home residents with diabetes at admission. J Am Med Dir Assoc 2004;5(5):320-327.

2. Maurer MS, Burcham J, Cheng H. Diabetes mellitus is associated with an increased risk of falls in elderly residents of a long-term care facility. J Gerontol A Biol Sci Med Sci 2005;60(9):1157-1162.

3. Schwartz AV, Sellmeyer DE, Ensrud KE, et al; Study of Osteoporotic Fractures Research Group. Older women with diabetes have an increased risk of fracture: A prospective study. J Clin Endocrinol Metab 2001;86(1):32-38.

4. Gregg EW, Mangione CM, Cauley JA, et al; Study of Osteoporotic Fractures Research Group. Diabetes and incidence of functional disability in older women. Diabetes Care 2002;25(1):61-67.

5. Gregg EW, Yaffe K, Cauley JA, et al. Is diabetes associated with cognitive impairment and cognitive decline among older women? Study of Osteoporotic Fractures Research Group. Arch Intern Med 2000;160(2):174-180.

6. Lewis CM, Schrader R, Many A, et al. Diabetes and urinary incontinence in 50to 90-year-old women: A cross-sectional population-based study. Am J Obstet Gynecol 2005;193(6):2154-2158.

7. Newman SC, Hassan AI. Antidepressant use in the elderly population in Canada: Results from a national survey. J Gerontol A Biol Sci Med Sci 1999;54(10):M527-M530.

8. Greene DA, Stevens MJ, Feldman EL. Diabetic neuropathy: Scope of the syndrome. Am J Med 1999;107(2B):2S-8S.

9. Brown AF, Mangione CM, Saliba D, Sarkisan CA; California Healthcare Foundation/American Geriatrics Society Panel on Improving Care for Elders with Diabetes. Guidelines for improving the care of the older person with diabetes mellitus. J Am Geriatr Soc 2003;51(5 Suppl Guidelines):S265-S280.

10. Saliba D, Solomon D, Rubenstein L, et al. Quality indicators for the management of medical conditions in nursing home residents. J Am Med Dir Assoc 2004;5(5):297-309.

11. American Diabetes Association. Standards of medical care in diabetes—2006. Diabetes Care 2006;29(Suppl 1):S4-S42. [Erratum in: Diabetes Care 2006;29(5):1192.

12. Durso SC. Using clinical guidelines designed for older adults with diabetes mellitus and complex health status. JAMA 2006;295(16):1935-1940.

13. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospectives Diabetes Study (UKPDS) Group. Lancet 1998;352(9131):837-853. [Erratum in: Lancet 1999;354(9178):602.]

14. Harris R, Donahue K, Rathore SS, et al. Screening for type 2 diabetes: A review of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 2003;138(3):215-229.

15. Shaughnessy AF, Slawson DC. What happened to the valid POEMs? A survey of review articles on the treatment of type 2 diabetes. BMJ 2003;327(7409):266.

16. Huang ES, Gorawara-Bhat R, Chin MH. Self-reported goals of older patients with type 2 diabetes mellitus. J Am Geriatr Soc 2005;53(2):306-311.

17. Van Bemmel T, Gussekloo J, Westendorp R, Biauw GJ. In a population-based prospective study, no association between high blood pressure and mortality after age 85 years. J Hypertens 2006;24(2):287-292

18. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs. diuretic. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002;288(23):2981-2997. [Erratum in: JAMA2003;289(2):178.] [Erratum in: JAMA 2004;291(18):2196.]

19. Brenner BM, Cooper ME, deZeeuw D, et al; RENAAL Study Investigators. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001;345(12):861-869.

20. Lewis EJ, Hunsicker LG, Clarke WR, et al; Collaborative Study Group. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 2001;345(12):851-860.

21. Tinetti ME. Clinical practice. Preventing falls in elderly persons. N Engl J Med 2003;348(1):42-49.

22. Colhoun HM, Betteridge DJ, Durrington PN, et al; CARDS Investigators. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomized placebo-controlled trial. Lancet 2004;364(9435):685-696.

23. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomized placebo-controlled trial. Lancet 2002;360(9326):7-22.

24. Weverling-Rijnsburger AW, Blauw GJ, Lagaay AM, et al. Total cholesterol and risk of mortality in the oldest old. Lancet 1997;350(9085):1119-1123.

25. Hovens MM, Tamsma JT, Beishuizen ED, Huisman MV. Pharmacological strategies to reduce cardiovascular risk in type 2 diabetes mellitus: An update. Drugs 2005;65(4):433-445.

26. Coulston AM, Mandelbaum D, Reaven GM. Dietary management of nursing home residents with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1990;51(1):67-71.

27. Buckler DA, Kelber ST, Goodwin JS. The use of dietary restrictions in malnourished nursing home patients. J Am Geriatr Soc 1994;42(10):1100-1102.

28. Mooradian AD, Osterweil D, Petrasek D, Morley JE. Diabetes mellitus in elderly nursing home patients: A survey of clinical characteristics and management. J Am Geriatr Soc 1988;36(5):391-396.

29. Zarowitz BJ, Tangalos EG, Hollenack K, O’Shea T. The application of evidence-based principles of care in older persons (issue 3): Management of diabetes mellitus. J Am Med Dir Assoc 2006;7(4):234-240.

30. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352(9131):854-865. [Erratum in: Lancet 1998;352(9139):1558.]

31. Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2006;(1):CD002967.

32. Van Staa T, Abenhaim L, Monette J. Rates of hypoglycemia in users of sulfonylureas. J Clin Epidemiol 1997;50(6):735-741.

33. Davis S, Alonso MD. Hypoglycemia as a barrier to glycemic control. J Diabetes Complications 2004(1);18:60-68.

34. Haas L. Management of diabetes mellitus medications in the nursing home. Drugs Aging 2005;22(3):209-218.

35. Nesto RW, Bell D, Bonow RO, et al. Thiazolidinedione use, fluid retention, and
congestive heart failure; A consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care 2004;27(1):256-263.

36. Vijan S, Hayward RA, Ronis DL, Hofer TP. Brief report: The burden of diabetes therapy: Implications for the design of effective patient-centered treatment regimens. J Gen Intern Med 2005;20(5):479-482.

37. Brandeis GH, Ooi WL, Hossain MM, et al. A longitudinal study of risk factors associated with the formation of pressure ulcers in nursing homes. J Am Geriatr Soc 1994;42(4):388-393.

38. Gradman TJ, Laws A, Thompson LW, Reaven GM. Verbal learning and/or memory improves with glycemic control in older subjects with non-insulin-dependent diabetes mellitus. J Am Geriatr Soc 1993;41(12):1305-1312.

39. Meneilly GS, Cheung E, Tessier D, et al. The effect of improved glycemic control on cognitive functions in the elderly patient with diabetes. J Gerontol 1993;48(4):M117-M121.

40. Lifford KL, Curhan GC, Hu FB, et al. Type 2 diabetes mellitus and risk of developing urinary incontinence. J Am Geriatr Soc 2005;53(11):1851-1857.

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