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Q& A With the Expert on: Constipation

  • Fri, 9/5/08 - 4:54pm
  • 0 Comments
  • 2530 reads
Author(s): 

Syed H. Tariq MD, FACP

Q: How do you manage constipation in the long-term care setting?

A: There is no clinical definition of constipation. Physicians describe constipation as less than three bowel movements per week, while patients describe constipation as passing hard stools or straining to have a bowel movement. Thus, there is no agreement between the patient and physician. Because of this dispute about the definition, there is little correlation between self-reported constipation and number of bowel movement in epidemiologic surveys. The Rome Criteria defines constipation as outlined in Table I, a consensus definition used by experts for the primary purpose of use in clinical trials.

The prevalence of self-reported constipation and laxative use increases with aging, while the prevalence of stool frequency does not change with age.1, 2 Constipation is more common in the elderly, African-Americans, women, and persons of lower socioeconomic class.

In frail elderly individuals, up to 45% reported constipation as a health issue. The prevalence of constipation is higher in nursing home residents, a finding not well explained by the increased use of laxatives, but which could be explained with higher use of medications and other comorbidities.3

Factors associated with constipation development in nursing homes include: race, decreased fluid intake, pneumonia, Parkinson’s disease, and presence of allergies.4 Congestive heart failure and the use of a feeding tube were two factors identified as having a protective effect.4

The average cost per long-term care resident with constipation is $2253.5 Health-related quality of life is reduced in patients with chronic constipation.6 The presence of constipation has been hypothesized to increase urinary tract symptoms, fecal incontinence, fecal impaction, and stercoral ulceration.7-9

CAUSES OF CONSTIPATION
Causes of constipation can be divided into primary and secondary causes.

Primary causes of constipation could be classified into three groups: (1) normal transit constipation, (2) slow transit constipation, and (3) anorectal dysfunction. Secondary causes are outlined in Table II. The most common ones are medications and coexistent medical conditions.

EVALUATION OF CONSTIPATION
Regulatory guidelines require that a comprehensive patient assessment, the Minimum Data Set (MDS), be completed within 14 days of admission to a nursing home. The MDS addresses how the resident uses the toilet, transfer on/off the toilet, and bowel pattern elimination. It is important to address constipation from the start, as it could lead to impaction, decrease in activities of daily living, incontinence of bowel and bladder, and at times, delirium, which could lead to resident assessment protocol trigger. Bowel elimination continues to be an important indicator on the MDS on the quarterly/annual assessment forms.

The steps involved in the evaluation of constipation are outlined in Table III. In acute or subacute onset, it is important to exclude structural lesions such as neoplasia or volvulus. The presence of weight loss along with rectal bleeding and/or iron deficiency anemia also requires examination of the colon to exclude cancer.

Additional tests that are used in the evaluation of constipation but are rarely needed in nursing home patients include colon transit measurements, colonic manometry, anorectal manometry, balloon expulsion testing, and defecography. Of patients undergoing extensive exhaustive investigations, the cause of constipation is determined in only about 50%.10

TREATMENT OF CONSTIPATION
The best strategy for managing constipation is to divide the symptoms into degrees of severity. The first step is to take a careful history, remembering that the patient often is talking about an entirely different symptom complex.

References: 

References

1. Harari D, Gurwitz JH, Avorn J, et al. Bowel habit in relation to age and gender: Findings from the National Health Interview Survey and clinical implications. Arch Intern Med 1996;156:315-320.

2. Everhart JE, Go VL, Johannes RS, et al. A longitudinal survey of self-reported bowel habits in the United States. Dig Dis Sci 1989;34:1153-1162.

3. Van Dijk KN, de Vries CS, van den Berg PB, et al. Constipation as an adverse effect of drug use in nursing home patients: An overestimated risk. Br J Clin Pharmacol 1998;46:255-261.

4. Robinson KM, Kiely DK. Lembo T. Development of constipation in nursing home residents. Dis Colon Rectum 2000;43(7);940-943.

5. Frank L, Schmier J, Kleinman, et al. Time and economic cost of constipation care in nursing homes. J Am Med Dir Assoc 2002;3(4):215-223.

6. Glia A, Lindberg G. Quality of life in patients with different types of functional constipation. Scand J Gastroenterol 1997;32:1083-1089.

7. Charach G, Greenstien A, Rabinovich P, et al. Alleviating constipation in the elderly improves lower urinary tract symptoms. Gerontology 2001;47:72-76.

8. Lynch AC, Dobbs BR, Keating J, Frizelle FA. The prevalence of faecal incontinence and constipation in a general New Zealand population: A postal survey. N Z Med J 2001;114:474-477.

9. Maull Ki, Kinning WK, Kay S. Stercoral ulceration. Am Surg 1982;48:20-24.

10. Whitehead WE, Drinkwater D, Cheskin LJ, et al. Constipation in the elderly living at home. Definition, prevalence, and relationship to lifestyle and health status. J Am Geriatr Soc 1989;37:423-429.

11. Ashraf W, Srb F, Lof J, Quigley EM. Idiopathic constipation: Subjective complaints vs. objective assessment [abstract]. Gastroenterology 1994;106:A461

12. Hull C, Greco RS, Brooks DL. Alleviation of constipation in the elderly by dietary fiber supplementation. J Am Geriatr Soc 1980;28:400-414.

13. Prather CM, Ortiz-Camacho CP. Evaluation and treatment of constipation and fecal impaction in adults. Mayo Clin Proc 1988;73:881-887.

14. Wrenn K. Fecal impaction. N Engl J Med 1989;321:658-662.

15. Muller-Lissner SA, Kamm MA, Scarpignato C, Wald A. Myths and misconceptions about chronic constipation. Am J Gastroenterol 2005;100:232-242.

16. Meshkinpour H, Selod S, Movahedi H, et al. Effects of regular exercise in management of chronic idiopathic constipation. Dig Dis Sci 1998;43:2379-2383.

17. Towers AL, Burgio KL, Locher JL, et al. Constipation in the elderly: Influence of dietary, psychological, and physiological factors. J Am Geriatr Soc 1994;78:701-706.

18. Tramonte SM, Brand MB, Murlow CD, et al. The treatment of chronic constipation in adults. A systematic review. J Gen Inter Med 1997;12:15-24.

19. Badiali D, Corazziari E, Habib FI, et al. Effect of wheat bran in treatment of chronic nonorganic constipation. A double-blind controlled trial. Dig Dis Sci 1995;40:349-356.

20. Cheskin LJ, Kamal N, Crowell MD, et al. Mechanisms of constipation in older persons and effects of fiber compared with placebo. J Am Geriatr Soc 1995;43(6):666-669.

21. Wald A. Constipation in elderly patients: pathogenesis and management. Drugs Aging 1993;3:220-231.

22. Schneider A, Bourquain W. Fournier gangrene following soap enemas. Zentrabl Chir 1988;113:397-399.

23. Castle SC, Cantrell M, Israel DS, Samuelson MJ. Constipation prevention: empiric use of stool softeners questions. Geriatrics 1991;46:84-86.

24. McRorie JW, Daggy BP, Morel JG, Diersing PS, Miner PB, Robinson M. Psyllium is superior to docusate sodium for treatment of chronic constipation. Alimentary Pharmacology & Therapeutics 1998;12:491-497.

25. Ashraf W, Park F, Lof J, Quigley EM. Effects of psyllium therapy on stool characteristics, colon transit and anorectal function in chronic idiopathic constipation. Randomized Controlled Trial. Alimentary Pharmacology & Therapeutics 1995;9:639-647.

26. Corazziari E, Badiali D, Bazzocchi G, et al. Long term efficacy, safety, and tolerability of low daily doses of isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in the treatment of functional chronic constipation. Gut 2000;46:522-526.

27. Sanders JF. Lactulose syrup assessed in a double-blind study of elderly constipated patients. J Am Geriatr Soc 1978;26:236-239.

28. Lederle FA, Busch DL, Mattox KM, et al. Cost-effective treatment of constipation in the elderly: A randomized double-blind comparison of sorbitol and lactulose. Am J Med 1990;89:597-601.

29. Vanderdonckt J, Coulon J, Denys W, Ravelli GP. Study of the laxative effect of lactitol in the elderly institutionalized, but not bedridden, population suffering from chronic constipation. J Clin Exp Gerontol 1990;12:171-189.

30. Maddi VI. Regulation of bowel function by a laxative/stool softener preparation in aged nursing home patients. J Am Geriatr Soc 1979;27:464-468.

31. Marchesi M. A laxative mixture in the therapy of constipation in aged patients. Giornale di Clinica Medica 1982;63:850-863.

32. Johanson JF, Wald A, Tougas G, Chey WD, Novick JS, Lembo AJ, Fordham F, Guella M, Nault B. Effect of tegaserod in chronic constipation: a randomized, double-blind, controlled trial. Clinical Gastroenterology & Hepatology 2004;2:796-805.

33. Orr KK. Lubiprostone: A novel chloride channel activator for the treatment of constipation. Formulary 2006;41:118-120, 122, 128-129.

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